pentobarbital will reduce the extent or result of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is mainly metabolized by CYP3A4; stay away from use in clients who are chronically employing a robust CYP3A4 inducerWatch Carefully (1)pentobarbital will reduce the exte